دورية
Abstract 12067: Prospective Utility of ST2 in Patients Hospitalized With Acute Decompensated Heart Failure
| العنوان: | Abstract 12067: Prospective Utility of ST2 in Patients Hospitalized With Acute Decompensated Heart Failure |
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| المؤلفون: | Li, Brian, Dowley, Michaela, Langley, Samantha, Hardy-Wallace, Amy, Cliffe, Paraic, whiting, Stephen, Phen, Pat, Harris, Stuart, Barbagallo, Rossella, Dungu, Jason, Savage, Henry Oluwasefunmi O |
| المصدر: | Circulation (Ovid); November 2021, Vol. 144 Issue: Supplement 1 pA12067-A12067, 1p |
| مستخلص: | Introduction:The soluble ST2 (sST2) biomarker is upregulated in response to myocardial strain, remodeling and fibrosis, and may play a role in risk stratification of patients with decompensated Heart Failure with a Reduced Ejection Fraction (HFrEF). The widely accepted prognostic sST2 cut-off for chronic HF is 35ng/ml. What this value would be for acute HF is debated.Objectives:To determine the prognostic value of sST2 in patients admitted with acute decompensated HFrEF.Methods:Between January 2020 and June 2021, consecutive patients hospitalized with HFrEF had sST2 measured at admission (within 24 hours) and at recompensation, as part of the INST2ANT-HF study (UK REC no:19/EE/0269). To determine an appropriate prognostic cut-off, we evaluated the median sST2 in our group as a potential threshold. The primary outcome was mortality at one year. Cumulative incidences, and the relationship between several clinical variables were tested in a Cox multivariate model for the primary outcome and comparisons between groups for events was performed using the χ2 test.Results:In the first 34 consecutive patients (Male 64%, AF 38%) with complete follow up (FU) data, median (IQR) FU was 405 (262-438)days. Median (IQR) age, 77 (60-85)years, mean (SD) EF, 27.9(±12.1). Median (IQR) eGFR, 62 (50-83)ml/min/1.73m2. Median (IQR) admission sST2 was 68 (43-91)ng/ml and admission NTproBNP was 7307 (5019-12809)ng/L. The primary endpoint occurred more frequently in patients with admission sST2>68ng/ml (p<0.01) (Fig.1).Conclusion:Our data suggests that in an unselected population of patients admitted with acute decompensated HFrEF, an admission sST2 value >68ng/ml has important prognostic value. Patients with high sST2 values on presentation require close follow up and a lower threshold for consideration of advanced HF therapies. A higher sST2 prognostic cut-off compared to CHF patients may hence be required for risk stratification. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00097322 15244539 |
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| DOI: | 10.1161/circ.144.suppl_1.12067 |