دورية
SLCO1B1variants and the risk of antituberculosis drug-induced hepatotoxicity: a systematic review and meta-analysis
| العنوان: | SLCO1B1variants and the risk of antituberculosis drug-induced hepatotoxicity: a systematic review and meta-analysis |
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| المؤلفون: | Zhu, Min, Chen, Xinyu, Hao, Zhuolu, He, Yiwen, Han, Bing, Tang, Shaowen |
| المصدر: | Pharmacogenomics; November 2023, Vol. 24 Issue: 18 p931-942, 12p |
| مستخلص: | Aims:To evaluate the association between SLCO1B1gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxicity (ATDH). Methods:We searched the PubMed, Cochrane Library, Embase, Web of Science, Wan Fang and China National Knowledge Infrastructure database from inception to 2022. Results:Nine case–control studies with 1129 cases and 2203 controls were included. Among four SNPs reported in two or more studies, the final results indicated that SNP rs4149014 was significantly associated with decreased ATDH risk (dominant model, odds ratio: 0.73; 95% CI: 0.55–0.97; p = 0.03; allele model, odds ratio: 0.69; 95% CI: 0.55–0.86; p = 0.001), and the trial sequential analysis also confirmed this significant association. Conclusion:SLCO1B1gene SNP rs4149014 was significantly associated with lower risk of ATDH susceptibility. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 14622416 17448042 |
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| DOI: | 10.2217/pgs-2023-0168 |