التفاصيل البيبلوغرافية
| العنوان: |
Whole genome resequencing reveals the genetic basis of albinophenotype in an ornamental fish, Channa asiatica |
| المؤلفون: |
Yuan, Dengyue, Li, Junting, Wang, Siya, Fu, Suxing, Gao, He, Duan, Yuting, Zhou, Yinhua, Li, Hejiao, Zhou, Chaowei |
| المصدر: |
Aquaculture Reports; June 2024, Vol. 36 Issue: 1 |
| مستخلص: |
Body color is one of the most noticeable phenotypic and economic characteristics in fish. Fish exhibit a diverse array of body color mutations influenced by factors such as artificial selection and natural mutations. Elucidating the genetic mechanisms of these color variants in fish is crucial for developing new breeds with higher ornamental value. In this study, we identified a nonsense mutation in csf1ra(c. 1249 C>T) with whole genome resequencing technology, and which may potentially contribute to the albinophenotype in Channa asiatica. The albinoindividuals exhibited a substantial decrease in the expression level of csf1racompared to that of the wild individuals. To unravel the underlying mechanism of csf1ra, we delved into comparative transcriptomic and gene expression analyses. Our findings suggest that csf1ramay impact tyrosine kinase activity. Furthermore, csf1ramay not only regulate the expression levels of genes (sox9, ephb6, and wnt9) involved in melanin-based pigmentation but also influence genes (ampd3, ak1, and bco1) associated with non-melanin-based pigmentation. Our study investigated the genetic basis of the albinomutant of C. asiaticaand provided new insights into the function of csf1rain fish pigmentation. |
| قاعدة البيانات: |
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