دورية
Expression and Characterization of atrplHomolog from Rat
| العنوان: | Expression and Characterization of atrplHomolog from Rat |
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| المؤلفون: | Preuß, Klaus-Dieter, Nöller, Joachim K., Krause, Elmar, Göbel, Alexandra, Schulz, Irene |
| المصدر: | Biochemical and Biophysical Research Communications; November 1997, Vol. 240 Issue: 1 p167-172, 6p |
| مستخلص: | Mammalian homologues of the Drosophila trp/trpl-gene-family code for “Ca2+-store-operated” channels. Here we describe the cloning and expression of atrp/trplhomologous gene from rat brain. The clone is namedRtrp3because of its high homology to the recently describedHtrp3(Zhu et al (1996) Cell 85:661-671). Expression ofRtrp3in the mammalian COS-1 cell line leads to 100 % increase of capacitative Ca2+entry as compared to the controls. This capacitative calcium entry can be completely blocked with La3+(10 μM). We conclude thatRtrp3,a new member of the growing family oftrp/trplhomologues in mammalians, is involved in “Ca2+-store-operated” Ca2+entry into the cell. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 0006291X 10902104 |
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| DOI: | 10.1006/bbrc.1997.7528 |