دورية
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans.
| العنوان: | Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans. |
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| المؤلفون: | Kelly, W G, Fire, A |
| المصدر: | Development; July 1998, Vol. 125 Issue: 13 p2451-6, 6p |
| مستخلص: | The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing mechanism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and mes-6. The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478). These results suggest that a genetic silencing process is essential for sustained germline function, and that this silencing is mediated, at least in part, by Polycomb Group proteins. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 09501991 14779129 |
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