دورية
Elongated Telomeres inscidMice
| العنوان: | Elongated Telomeres inscidMice |
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| المؤلفون: | Hande, Prakash, Slijepcevic, Predrag, Silver, Andy, Bouffler, Simon, van Buul, Paul, Bryant, Peter, Lansdorp, Peter |
| المصدر: | Genomics; March 1999, Vol. 56 Issue: 2 p221-223, 3p |
| مستخلص: | Severe combined immunodeficiency (scid) mice are deficient in the enzyme DNA-PK (DNA-dependent protein kinase) as a result of the mutation in the gene encoding the catalytic subunit (DNA-PKcs) of this enzyme. DNA-PKcs is a member of the phosphatidylinositol 3-kinase superfamily, which includes the human protein ATM (ataxia telangiectasia mutated) and the yeast protein Tel1. Using Q-FISH (quantitative fluorescencein situhybridization), we show here thatscidmice from four different genetic backgrounds have, on average, 1.5–2 times longer telomeres than those of corresponding wild-type mice. Our results point to the possibility that DNA-PKcs may, directly or indirectly, be involved in telomere length regulation in mammalian cells. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 08887543 10898646 |
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| DOI: | 10.1006/geno.1998.5668 |