دورية
Naturally Elicited Antibodies to Glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum Require Intact GPI Structures for Binding and Are Directed Primarily against the Conserved Glycan Moiety
| العنوان: | Naturally Elicited Antibodies to Glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum Require Intact GPI Structures for Binding and Are Directed Primarily against the Conserved Glycan Moiety |
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| المؤلفون: | Naik, Ramachandra S., Krishnegowda, Gowdahalli, Ockenhouse, Christian F., Gowda, D. Channe |
| المصدر: | Infection and Immunity; February 2006, Vol. 74 Issue: 2 p1412-1415, 4p |
| مستخلص: | Immunization with a synthetic glycan corresponding to Plasmodium falciparum glycosylphosphatidylinositols (GPIs) has been proposed as a vaccination strategy against malaria. We investigated the structural requirements for binding of naturally elicited anti-GPI antibodies to parasite GPIs. The data show that anti-GPI antibody binding requires intact GPI structures and that the antibodies are directed predominantly against GPIs with a conserved glycan structure with three mannoses and marginally against the terminal fourth mannose. The results provide valuable insight for exploiting GPIs for the development of malaria vaccines. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00199567 10985522 |
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