دورية
Potential Antimalarials. X. Di-Mannich Bases of 4-(7'-Trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine
| العنوان: | Potential Antimalarials. X. Di-Mannich Bases of 4-(7'-Trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine |
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| المؤلفون: | Barlin, GB, Jiravinyu, C |
| المصدر: | Australian Journal of Chemistry; 1990, Vol. 43 Issue: 7 p1175-1181, 7p |
| مستخلص: | The syntheses of some di-Mannich bases derived from 4-(7′-trifluoromethyl-1′,5′-naphthyridin-4′-ylamino) phenol and of N-(4′-diethylamino-11′-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine from 3-chloro-5-trifluoromethylpyridine via4-chloro-7- trifluoromethyl-1,5-naphthyridine are described. In tests in vitro against the FCQ-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00049425 14450038 |
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| DOI: | 10.1071/CH9901175 |