دورية
Patients with Systemic Lupus Erythematosus Show Increased Platelet Activation and Endothelial Dysfunction Induced by Acute Hyperhomocysteinemia
| العنوان: | Patients with Systemic Lupus Erythematosus Show Increased Platelet Activation and Endothelial Dysfunction Induced by Acute Hyperhomocysteinemia |
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| المؤلفون: | Tam, Lai-Shan, Fan, Boli, Li, Edmund, Thomas, G., Yim, PL, Haines, Christopher, Tomlinson, Brian |
| المصدر: | Journal of Rheumatology; 07/1/2003, Vol. 30 Issue: 7 p1479-14841484, 14840006p |
| مستخلص: | OBJECTIVE:. Hyperhomocysteinemia adversely affects the endothelium, although the exact mechanism is unclear. Systemic lupus erythematosus (SLE) is an inflammatory disease with a high atherothrombotic tendency. We examined whether acute hyperhomocysteinemia exacerbates endothelial and platelet dysfunction in patients with SLE. METHODS: Twelve SLE patients and 15 controls were recruited. Oral methionine was used to achieve acute hyperhomocysteinemia. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery; also assessed were the levels of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1). Platelet activation was assessed by the levels of beta-thromboglobulin (β-TG), fibrinogen binding, and P-selectin expression using flow cytometry. RESULTS: After oral methionine loading, vWF levels increased significantly, whereas FMD remained unchanged in both groups. PAI-1 increased significantly only in controls. Fibrinogen binding to platelets increased significantly only in SLE patients. β-TG remained unchanged in SLE patients but increased significantly in controls. Platelet P-selectin expression did not change in either group. CONCLUSION: These results suggest that the prothrombotic tendency after acute hyperhomocysteinemia is mediated by endothelial dysfunction and platelet activation in patients with SLE and healthy controls. |
| قاعدة البيانات: | Supplemental Index |
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