Genetic susceptibility variants associated with colorectal cancer prognosis
| العنوان: | Genetic susceptibility variants associated with colorectal cancer prognosis |
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| المؤلفون: | Abuli, A, Lozano, JJ, Rodriguez-Soler, M, Jover, R, Bessa, X, Munoz, J, Esteban-Jurado, C, Fernandez-Rozadilla, C, Carracedo, A, Ruiz-Ponte, C, Cubiella, J, Balaguer, F, Bujanda, L, Rene, JM, Clofent, J, Morillas, JD, Nicolas-Perez, D, Xicola, RM, Llor, X, Pique, JM, Andreu, M, Castells, A, Castellvi-Bel, S, Martin, M, Spanish Gastroenterological Assoc |
| المصدر: | CARCINOGENESIS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | OXFORD UNIV PRESS, 2013. |
| سنة النشر: | 2013 |
| الوصف: | Colorectal cancer (CRC) is the second leading cause of cancer-related death among men and women in Western countries. Once a tumour develops, a differentiated prognosis could be determined by lifestyle habits or inherited and somatic genetic factors. Finding such prognostic factors will be helpful in order to identify cases with a shorter survival or at a higher risk of recurrence that may benefit from more intensive treatment and follow-up surveillance. Sixteen CRC genetic susceptibility variants were directly genotyped in a cohort of 1235 CRC patients recruited by the EPICOLON Spanish consortium. Univariate Cox and multivariate regression analyses were performed taking as primary outcomes overall survival (OS), disease-free survival and recurrence-free interval. Genetic variants rs9929218 at 16q22.1 and rs10795668 at 10p14 may have an effect on OS. The G allele of rs9929218 was linked with a better OS [GG genotype, genotypic model: hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.450.93, P 0.0179; GG/GA genotypes, dominant model: HR 0.66, 95% CI 0.470.94, P 0.0202]. Likewise, the G allele of rs10795668 was associated with better clinical outcome (GG genotype, genotypic model: HR 0.73, 95% CI 0.531.01, P 0.0570; GA genotype, genotypic model: HR 0.66, 95% CI 0.470.92, P 0.0137; GG/GA genotypes, dominant model: HR 0.68, 95% CI 0.500.94, P 0.0194). In conclusion, CRC susceptibility variants rs9929218 and rs10795668 may exert some influence in modulating patients survival and they deserve to be further tested in additional CRC cohorts in order to confirm their potential as prognosis or predictive biomarkers. |
| تدمد: | 0143-3334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::de383a402b71162d6320a14d36d6c6a8 https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9647 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.RECOLECTA.....de383a402b71162d6320a14d36d6c6a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01433334 |
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