Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial
| العنوان: | Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial |
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| المؤلفون: | Creutzberg, CL, van Putten, WLJ, Koper, PCM, Lybeert, MLM, Jobsen, JJ, Warlam-Rodenhuis, CC, De Winter, KAJ, Lutgens, LCHW, van den Bergh, ACM, van de Steen-Banasik, E, Beerman, H, van Lent, M |
| المساهمون: | Radiotherapy, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| المصدر: | Lancet (UK), 355, 1404-1411. Elsevier Ltd. LANCET, 355(9213), 1404-1411. ELSEVIER SCIENCE INC |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | VAGINAL IRRADIATION, CLINICAL STAGE, TREATMENT FAILURE, PROGNOSTIC FACTORS, EXTERNAL IRRADIATION, RISK-FACTORS, ADENOCARCINOMA, GYNECOLOGIC-ONCOLOGY-GROUP, ADJUVANT RADIOTHERAPY, CANCER |
| الوصف: | Background Postoperative radiotherapy for international Federation of Gynaecology and Obstetrics (FIGO) stage-1 endometrial carcinoma is a subject of controversy due to the low relapse rate and the lack of data from randomised trials. We did a multicentre prospective randomised trial to find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma. Methods Patients with stage-1 endometrial carcinoma (grade 1 with deep [greater than or equal to 50%] myometrial invasion, grade 2 with any invasion, or grade 3 with superficial [ Findings Analysis was done according to the intention-to-treat principle. Of the 715 patients, 714 could be evaluated. The median duration of follow-up was 52 months. 5-year actuarial locoregional recurrence rates were 4% in the radiotherapy group and 14% in the control group (p Interpretation Postoperative radiotherapy in stage-1 endometrial carcinoma reduces locoregional recurrence but has no impact on overall survival, Radiotherapy increases treatment-related morbidity. Postoperative radiotherapy is not indicated in patients with stage-1 endometrial carcinoma below 60 years and patients with grade-2 tumours with superficial invasion. |
| تدمد: | 0140-6736 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00725016d8f60d58244e01c88079cca4 https://pure.eur.nl/en/publications/2651b582-de02-4d2c-b382-f0df16e9d577 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.dedup.wf.001..00725016d8f60d58244e01c88079cca4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01406736 |
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