Evaluation of diterpenoids from P. ornatus as potential COX-1 inhibitors

التفاصيل البيبلوغرافية
العنوان: Evaluation of diterpenoids from P. ornatus as potential COX-1 inhibitors
المؤلفون: Rijo, P., Fernandes, As, Simões, F., Lídia Pinheiro
المصدر: Journal Biomedical and Biopharmaceutical Research (BBR), Vol 9, Iss 1, Pp 111-118 (2012)
ResearcherID
بيانات النشر: ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde, 2012.
سنة النشر: 2012
مصطلحات موضوعية: lcsh:Therapeutics. Pharmacology, lcsh:RM1-950, diterpenoids, Plectranthus ornatus, COX-1 inhibitors
الوصف: Natural products are a rich source of drug candidates for clinical use. The Plectranthus ornatus Codd. belongs to a genus associated to the isolation of diterpenoids which are responsible for various biological activities. The three diterpenoids under study were isolated in the past from P. ornatus and are now being evaluated as potential COX-1 inhibitors. Obtained results suggest that rhinocerotinoic acid (2), but not halimane (3) and plectrornatin C (1), has a mild COX-1 inhibitory activity. Current studies are being carried out to understand if these compounds have effect as COX-2 inhibitors. This will contribute to establish their possible interest as anti-inflammatory agents.
اللغة: English
تدمد: 2182-2379
2182-2360
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0adb9b76023e4c1deb56e5bfd71b2905
حقوق: OPEN
رقم الأكسشن: edsair.dedup.wf.001..0adb9b76023e4c1deb56e5bfd71b2905
قاعدة البيانات: OpenAIRE