[The translation of genetic risk variants to molecular disease mechanisms]
| العنوان: | [The translation of genetic risk variants to molecular disease mechanisms] |
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| المؤلفون: | Snijders, G., Snijders, R., LOTJE DE WITTE |
| المصدر: | Tijdschrift voor Psychiatrie, 64, 323-326 LOTJE DE WITTE Tijdschrift voor Psychiatrie, 64, 5, pp. 323-326 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] |
| الوصف: | Contains fulltext : 281797.pdf (Publisher’s version ) (Closed access) BACKGROUND: Genetic studies have found large numbers of genetic risk variants that increase the risk to develop neuropsychiatric disorders. AIM: We aim to explain how to investigate the effects of these genetic risk variants on the expression of genes and whether this plays a potential role in neuropsychiatric disorders. METHOD: We describe the main findings of a study that we recently performed to study the association between genetic risk factors for neuropsychiatric disorders and gene expression in microglia, the immune cells of the brain. RESULTS: Part of the risk variants for neuropsychiatric disorders could be related to gene expression in microglia. These associations were particularly strong for neurodegenerative disorders. CONCLUSION: Our study provided more insight into how genetic risk to neuropsychiatric disorders is related to gene expression in microglia. These findings show suggestions for potential new treatment options. |
| وصف الملف: | application/pdf |
| تدمد: | 0303-7339 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eed43fab9d3fc83011803495683ad202 https://hdl.handle.net/2066/281797 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..eed43fab9d3fc83011803495683ad202 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03037339 |
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