Objective: A meta-analysis was used to systematically study the correlation between inflammatory response and diabetic nephropathy based on Shenqi Dihuang Decoction. Methods: The RCT literatures related to the efficacy and inflammatory response of Shenqi Dihuang Decoction in the treatment of diabetic nephropathy in Chinese and English databases were searched. The time limit was from the establishment of the database to February 2020. Literature screening and data extraction were performed according to the criteria for inclusion and exclusion. The evaluator's manual 5.1.0 was used to evaluate the risk of bias in the final included literature. Meta-analysis was performed using RevMan 5.3 software. Comparing western medicine treatment and Shenqi Dihuang decoction to inflammatory factors: interleukin-6 (IL-6) Interleukin-8 (IL-8), tumor necrosis factor-毩(TNF-毩), C-reactive protein (CRP), intercellular adhesion molecule-1 (MCP-1), and monocyte chemotactic protein-1 (ICAM-1) and efficacy indicators: the impact of urine microalbumin (mALB) and clinical efficacy. Results: A total of 11 related research reports were finally included, of which 9 evaluated IL-6 [SMD = -1.09, 95% CI (-1.57, -0.61),Z=4.43, P
