The aim of present study is to evaluate the anti-inflammatory, anti-pyretic and analgesic activities of ethanol extract of Carica papaya L. on albino rats. Plant of C. papaya L. is commonly used to treat different diseases like fever, pain, and inflammation. A total of 144 albino rats with an average weight of 160-200g were used in this study. Rats were divided into 4 groups each group contained 12 rats. Anti-inflammatory activity was evaluated by 0.1 mL of 1% carrageenan extract that induces paw edema while analgesic activity was investigated by acetic acid that induces abdominal writhing response where antipyretic activity was demonstrated by yeast that induces pyrexia in rats. In anti-inflammatory, antipyretic and analgesic activities, significant results were shown at 400mg/kg, 50mg/kg and 400mg/kg doses respectively in multiple comparisons. The stem extract of C. papaya L. showed significant results as compared to leaf extract in anti-inflammatory and antipyretic activities. The leaf extract of C. papaya showed significant results as compared to the stem in analgesic activity.
