Rutin-loaded selenium nanoparticles modulated the redox status, inflammatory, and apoptotic pathways associated with pentylenetetrazole-induced epilepsy in mice
| العنوان: | Rutin-loaded selenium nanoparticles modulated the redox status, inflammatory, and apoptotic pathways associated with pentylenetetrazole-induced epilepsy in mice |
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| المؤلفون: | Kareem M. Mohamed, Mohamed S. Abdelfattah, Manal El-khadragy, Wafa A. Al-Megrin, Alaa Fehaid, Rami B. Kassab, Ahmed E. Abdel Moneim |
| المصدر: | Green Processing and Synthesis. 12 |
| بيانات النشر: | Walter de Gruyter GmbH, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Fuel Technology, Renewable Energy, Sustainability and the Environment, Health, Toxicology and Mutagenesis, General Chemical Engineering, Environmental Chemistry, Industrial and Manufacturing Engineering |
| الوصف: | Worldwide, epilepsy is the second most prevalent neurological disorder. Disappointingly, various adverse effects are being observed with currently used antiepileptic drugs. Nanomedicine represents an effective strategy to overcome these limitations with a better central drug delivery. Hence, our work aimed to unravel the antiepileptic efficacy of rutin (Rut) loaded with selenium nanoparticles (SeNPs) against pentylenetetrazole (PTZ)-challenged mice. Ten days before PTZ (60 mg·kg−1) intraperitoneal injection, mice were orally administered Rut (100 mg·kg−1), sodium selenite (0.5 mg·kg−1), SeNPs (100 mg·kg−1), or sodium valproate (reference drug, 200 mg·kg−1). Remarkably, administration of Rut-loaded SeNPs (Rut-SeNPs) to epileptic mice markedly increased the latency time and decreased the severity and duration of seizures. Remarkable increases were also noticed in acetylcholinesterase, brain-derived neurotrophic factor, dopamine, and norepinephrine levels in epileptic mice treated with Rut-SeNPs. Furthermore, Rut-SeNPs boosted the cellular antioxidant defense by increasing superoxide dismutase, catalase, GSH, Nrf2, and HO-1, along with decreased malondialdehyde and nitric oxide levels. In addition, the nanotherapy successfully mitigated the inflammatory mediators (tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, and nuclear factor kappa B) in mice hippocampus. Rut-SeNPs antagonized neuronal apoptosis by decreasing Bax and caspase-3 and increasing the levels of Bcl-2. Conclusively, the present work suggests Rut-loaded SeNPs as an effective antiepileptic therapy through correction of disturbed neurotransmitters, oxidative status, neuroinflammation, and apoptosis. |
| تدمد: | 2191-9550 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::07aa0bc0124b1a8c6209aaefcb99e929 https://doi.org/10.1515/gps-2023-0010 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........07aa0bc0124b1a8c6209aaefcb99e929 |
| قاعدة البيانات: | OpenAIRE |
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