Vitamin A deficiency creates persistent shedding of Citrobacter rodentium and potential reservoirs for the spread of enteric pathogens (MUC5P.755)
| العنوان: | Vitamin A deficiency creates persistent shedding of Citrobacter rodentium and potential reservoirs for the spread of enteric pathogens (MUC5P.755) |
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| المؤلفون: | Kaitlin McDaniel, Katherine Restori, Jeffery Dodds, Mary Kennett, A. Ross, Margherita Cantorna |
| المصدر: | The Journal of Immunology. 194:138.13-138.13 |
| بيانات النشر: | The American Association of Immunologists, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Vitamin A deficiency remains a public health concern in developing countries and is associated with increased susceptibility to infectious disease and childhood mortality. We utilized Citrobacter rodentium to model human enteric infections. 40% of vitamin A deficient (A-) mice developed a severe and lethal infection. All of the vitamin A sufficient (A+) mice survived and cleared the infection by day 25. Retinoic acid (RA, active form of vitamin A) treatment of A- mice before and at the time of infection resulted in clearance of C. rodentium with the same kinetics as the A+ mice. Additionally, RA treatment of A- mice at the peak of the infection eliminated C. rodentium within 16 days of treatment. Although the A- mice remained infected at day 37, colon inflammation had resolved to that found in A+ mice. All of the A- and A+ mice were able to clear systemic challenge with C. rodentium indicating that A- mice are able to control systemic bacterial infection. Furthermore, the increased mortality of A- mice during infection was not due to systemic cytokine production or increased C. rodentium pathogenicity. Instead the A- mice seem to have developed a severe gut infection but 60% of the A- mice were able to survive and resolve the inflammation. Our work suggests that improvements in vitamin A status and/or RA treatments may decrease susceptibility to enteric pathogens and eliminate potential carriers from spreading infection to susceptible populations. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::1abf457d117190f00319144cf5a92cbf https://doi.org/10.4049/jimmunol.194.supp.138.13 |
| رقم الأكسشن: | edsair.doi...........1abf457d117190f00319144cf5a92cbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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