Preparation of Polyethylene Glycol Monomethyl Ether Chitosan-diethylenetriamine Pentaacetic Acid and Its Effect on 89SrCl2 Excretion and Radiation Protection in the Digestive Tract of Rats
التفاصيل البيبلوغرافية
العنوان:
Preparation of Polyethylene Glycol Monomethyl Ether Chitosan-diethylenetriamine Pentaacetic Acid and Its Effect on 89SrCl2 Excretion and Radiation Protection in the Digestive Tract of Rats
In this study, hydrophilic polymer polyethylene glycol monomethyl ether chitosan-diethylenetriamine pentaacetic acid (mPEGCS-DTPA) was synthesized via chemical synthesis and cross-linking, and its cytotoxicity and radiation protective effect in vivo were studied. The results revealed that mPEGCS-DTPA exhibits good cytocompatibility and increases the excretion of radionuclides through the digestiveand urinary tracts. The pathological results of the small intestine revealed that mPEGCS-DTPA exerts a good radiation-protective effect and could reduce the α and β-emitting radiation-induced damage of the intestinal mucosa. MPEGCS-DTPA can increase the excretion of radionuclides in the digestive tract and exhibits effective protection against radiation.
