ChemInform Abstract: Stereoisomeric Acylamidomorpholinium Carnitine Analogues: Selective Inhibitors of Carnitine Palmitoyltransferase I and II
| العنوان: | ChemInform Abstract: Stereoisomeric Acylamidomorpholinium Carnitine Analogues: Selective Inhibitors of Carnitine Palmitoyltransferase I and II |
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| المؤلفون: | Tak-Sing Lee, Prashant S. Savle, Richard D. Gandour, Shri V. Pande |
| المصدر: | ChemInform. 31 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Biochemistry, Chemistry, Microsome, medicine, General Medicine, Carnitine palmitoyltransferase I, Carnitine, Isozyme, medicine.drug |
| الوصف: | Acylamidomorpholinium carnitine analogues, 6-(tetradecanamidomethyl- and -hexadecanamidomethyl)-4,4-dimethylmorpholin-4-ium-2-acetate, 1 , synthesized as complete sets of stereoisomers, were assayed as inhibitors for isozymes of carnitine palmitoyltransferase (CPT). Microsomal CPT isozymes showed modest discrimination among the stereoisomer; while rat-liver mitochondrial CPT-I and CPT-II showed distinct differences. The tetradecanamidomethyl analogue of (2R,6S)- 1 activated CPT-I but inhibited CPT-II. |
| تدمد: | 1522-2667 0931-7597 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::28e0e00cf96774973762893595dad39c https://doi.org/10.1002/chin.200008189 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........28e0e00cf96774973762893595dad39c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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