Abstract 685: Wnt5a/JNK Signaling Mediates Endothelial Insulin Resistance in Human Diabetes
| العنوان: | Abstract 685: Wnt5a/JNK Signaling Mediates Endothelial Insulin Resistance in Human Diabetes |
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| المؤلفون: | Bihua Feng, Kenneth Walsh, Jessica L. Fetterman, Brittany D Berk, Erika A Linder, Noyan Gokce, Joseph A. Vita, Monika Holbrook, Naomi M. Hamburg, Melissa G. Farb, Rosa Bretón-Romero, Elica Inagaki, José J. Fuster |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology. 35 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, Endothelium, business.industry, Inflammation, medicine.disease, biology.organism_classification, Insulin receptor, Insulin resistance, medicine.anatomical_structure, Endocrinology, Enos, Internal medicine, Diabetes mellitus, biology.protein, medicine, Endothelial dysfunction, medicine.symptom, Signal transduction, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Diabetes mellitus (DM) is associated with endothelial dysfunction that contributes to the development of atherosclerosis and promotes cardiovascular disease. Recent work has identified the secreted Wnt5a as a pro-inflammatory mediator of metabolic dysfunction in obesity acting through a non-canonical signaling pathway involving JNK activation. In animal models, JNK activity has been widely described to be involved in systemic insulin resistance. However, the relevance of Wnt5a/JNK axis in the vasculature is unknown. Our study aimed to evaluate the involvement of Wnt5a/JNK in endothelial dysfunction, studying its potential role in altered eNOS activation and insulin signaling in patients with DM. We measured protein expression, and insulin response in freshly isolated endothelial cells (ECs) from patients with DM (n=26) and non-diabetic controls (n=32). ECs from patients with DM displayed impaired insulin-mediated eNOS activation and reduced NO release in conjunction with higher expression of Wnt5a (P=0.01). This effect was accompanied with an enhanced activation of JNK (P |
| تدمد: | 1524-4636 1079-5642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::2ff4ed22c64fdc7717b97caa14eea902 https://doi.org/10.1161/atvb.35.suppl_1.685 |
| رقم الأكسشن: | edsair.doi...........2ff4ed22c64fdc7717b97caa14eea902 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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