90Y-DOTA-CHS Microspheres for Live Radiomicrosphere Therapy: Preliminary In Vivo Lung Radiochemical Stability Studies
| العنوان: | 90Y-DOTA-CHS Microspheres for Live Radiomicrosphere Therapy: Preliminary In Vivo Lung Radiochemical Stability Studies |
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| المؤلفون: | Anthony J. McGoron, Alejandro Amor-Coarasa, Andrew Milera, Denny A. Carvajal, Seza A. Gulec |
| المصدر: | Journal of Radiotherapy. 2014:1-6 |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Materials science, Lung, Radiochemistry, Urine, In vitro, Chitosan, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, In vivo, medicine, Surface modification, DOTA, Bone marrow, Biomedical engineering |
| الوصف: | Chitosan (CHS) is used to prepare microspheres of 31 ± 8 µm size. Surface modification with p-SCN-Bn-DOTA was performed. A maximum 90Y capacity was found to be 12.1 ± 4.4 µCi/particle. The best obtained labeling yield was 87.7 ± 0.6%. More than 90% in vitro stability was found. Particle in vitro degradation half-life in PBS was found to be greater than 21 days. In vivo studies with 90Y-DOTA-CHS showed more than 95% of the injected activity (decay corrected) in the lungs 24 hours after tail vein administration. 90Y-DOTA-CHS in vivo label stability was superior to resin microspheres. The addition of p-SCN-Bn-DOTA served as a radioprotectant for bone marrow as the 5% 90Y released, during the first 24 hours, was quickly eliminated via urine. |
| تدمد: | 2314-8349 2356-7600 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::31746a551618c3ccfa8f1feebda0e93e https://doi.org/10.1155/2014/941072 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........31746a551618c3ccfa8f1feebda0e93e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23148349 23567600 |
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