Molecular mechanism of Helicobacter�pylori‑induced autophagy in gastric cancer (Review)
| العنوان: | Molecular mechanism of Helicobacter�pylori‑induced autophagy in gastric cancer (Review) |
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| المؤلفون: | Cong Chen, Fan Zhang, Zhi-Jian Han, Junqiang Zhang, Ruiliang Su, Jike Hu, Hao Chen, Yumin Li |
| المصدر: | Oncology Letters. |
| بيانات النشر: | Spandidos Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Innate immune system, biology, business.industry, Autophagy, Cellular homeostasis, Cancer, Helicobacter pylori, bacterial infections and mycoses, biology.organism_classification, medicine.disease, 03 medical and health sciences, Chronic infection, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Immunology, medicine, Gastritis, medicine.symptom, business, Pathogen |
| الوصف: | Helicobacter pylori (H. pylori) is a gram-negative pathogen that colonizes gastric epithelial cells. The drug resistance rates of H. pylori have dramatically increased, causing persistent infections. Chronic infection by H. pylori is a critical cause of gastritis, peptic ulcers and even gastric cancer. In host cells, autophagy is stimulated to maintain cellular homeostasis following intracellular pathogen recognition by the innate immune defense system. However, H. pylori-induced autophagy is not consistent during acute and chronic infection. Therefore, a deeper understanding of the association between H. pylori infection and autophagy in gastric epithelial cells could aid the understanding of the mechanisms of persistent infection and the identification of autophagy-associated therapeutic targets for H. pylori infection. The present review describes the role of H. pylori and associated virulence factors in the induction of autophagy by different signaling pathways during acute infection. Additionally, the inhibition of autophagy in gastric epithelial cells during chronic infection was discussed. The present review summarized H. pylori-mediated autophagy and provided insights into its mechanism of action, suggesting the induction of autophagy as a novel therapeutic target for persistent H. pylori infection. |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::395acb333528fa26a00d35387f2ddfed https://doi.org/10.3892/ol.2019.10976 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........395acb333528fa26a00d35387f2ddfed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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