Differences in engraftment with day-1 compared with day-2 melphalan prior to stem cell infusion in myeloma patients receiving autologous stem cell transplant
| العنوان: | Differences in engraftment with day-1 compared with day-2 melphalan prior to stem cell infusion in myeloma patients receiving autologous stem cell transplant |
|---|---|
| المؤلفون: | Eli Muchtar, Wilson I. Gonsalves, JaeWon Lee, Sarah Wittwer, Francis K. Buadi, Martha Q. Lacy, Angela Dispenzieri, Prashant Kapoor, David Dingli, Rahma Warsame, Taxiarchis Kourelis, Abdullah S. Al Saleh, William J. Hogan, Morie A. Gertz, Eapen K. Jacob, Shaji Kumar, M. Hasib Sidiqi, Nelson Leung, Robert C. Wolf, Christel A. Skaer |
| المصدر: | Bone Marrow Transplantation. 55:2132-2137 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Melphalan, Transplantation, medicine.medical_specialty, Neutrophil Engraftment, Platelet Engraftment, business.industry, medicine.medical_treatment, Retrospective cohort study, Hematology, Hematopoietic stem cell transplantation, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Cohort, medicine, Stem cell, business, 030215 immunology, medicine.drug |
| الوصف: | We conducted a retrospective study comparing posttransplant outcomes between myeloma patients receiving conditioning melphalan on day-2 vs day-1 for autologous stem cell transplant. Between January 2017 and December 2018, 201 patients received melphalan on day-2 and 166 on day-1 prior to stem cell infusion. Baseline disease and clinical characteristics between the two groups were similar. Although rates of hospitalization were similar between the cohorts, duration of hospital admission was longer for day-1 (median 7 days for day-1 vs 5 days for day-2, p = 0.003). Rates of fever were higher in the day-1 cohort (69% vs 49%, p = 0.0002). Time to platelet and neutrophil engraftment was significantly longer in the day-1 cohort (platelet engraftment median days 17 for day-1 vs 15 for day-2, p |
| تدمد: | 1476-5365 0268-3369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5265543892d899d1f5bae56e8e4c413a https://doi.org/10.1038/s41409-020-0916-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........5265543892d899d1f5bae56e8e4c413a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765365 02683369 |
|---|