التفاصيل البيبلوغرافية
| العنوان: |
Recent strategies in cartilage repair: A systemic review of the scaffold development and tissue engineering |
| المؤلفون: |
Vikrant Rai, Devendra K. Agrawal, Nicholas E. Dietz, Matthew F. Dilisio |
| المصدر: |
Journal of Biomedical Materials Research Part A. 105:2343-2354 |
| بيانات النشر: |
Wiley, 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
0301 basic medicine, Scaffold, Materials science, Cartilage, Cellular differentiation, Mesenchymal stem cell, Metals and Alloys, Biomedical Engineering, 02 engineering and technology, Osteoarthritis, 021001 nanoscience & nanotechnology, medicine.disease, Cell biology, Biomaterials, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Tissue engineering, Ceramics and Composites, medicine, Progenitor cell, 0210 nano-technology, Stem cell transplantation for articular cartilage repair |
| الوصف: |
Osteoarthritis results in irreparable loss of articular cartilage. Due to its avascular nature and low mitotic activity, cartilage has little intrinsic capacity for repair. Cartilage loss leads to pain, physical disability, movement restriction, and morbidity. Various treatment strategies have been proposed for cartilage regeneration, but the optimum treatment is yet to be defined. Tissue engineering with engineered constructs aimed towards developing a suitable substrate may help in cartilage regeneration by providing the mechanical, biological and chemical support to the cells. The use of scaffold as a substrate to support the progenitor cells or autologous chondrocytes has given promising results. Leakage of cells, poor cell survival, poor cell differentiation, inadequate integration into the host tissue, incorrect distribution of cells, and dedifferentiation of the normal cartilage are the common problems in tissue engineering. Current research is focused on improving mechanical and biochemical properties of scaffold to make it more efficient. The aim of this review is to provide a critical discussion on existing challenges, scaffold type and properties, and an update on ongoing recent developments in the architecture and composition of scaffold to enhance the proliferation and viability of mesenchymal stem cells. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2343–2354, 2017. |
| تدمد: |
1549-3296 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::57e0e024730bf425054b928f3d38c510
https://doi.org/10.1002/jbm.a.36087 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........57e0e024730bf425054b928f3d38c510 |
| قاعدة البيانات: |
OpenAIRE |
