Background HPV16 and 18 are the most common high-risk human papillomavirus (HPV) types causing cervical lesions. Women with HPV16 and/or 18(HPV16/18) infections are the main targets for cervical screening. But the HPV16/18 infection status is complex, and clarifying the risk of different infection patterns for cervical lesions is essential for subsequent management options. Our study aimed to assess the risk of HPV16 or 18 combined with other high-risk(HR) and/or low-risk(LR) HPV types for cervical lesions and their clinical characteristics. Methods In this retrospective study, we analyzed the clinical data of 3,217 patients with HPV16/18 infection.We divided HPV16 or HPV18 multiple infections into 8 patterns: HPV16 + HR, HPV16 + LR, HPV16 + HR + LR, HPV18 + HR, HPV18 + LR, HPV18 + HR + LR, HPV16 + 18 and HPV16 + 18 + other-HPV. The analysis of data was performed by Chi-square test and multinational logistic regression. P
