Trypanosomatid Cell Division Kinases
| العنوان: | Trypanosomatid Cell Division Kinases |
|---|---|
| المؤلفون: | Elizabeth B. Thomas, Corinna Benz, Tansy C. Hammarton |
| المصدر: | Protein Phosphorylation in Parasites Novel Targets for Antiparasitic Intervention |
| بيانات النشر: | Wiley-VCH Verlag GmbH & Co. KGaA, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | biology, Kinase, Drug discovery, RNA interference, parasitic diseases, Trypanosoma brucei, Cell cycle, Signal transduction, Trypanosoma cruzi, biology.organism_classification, Function (biology), Cell biology |
| الوصف: | Advances have been made recently in understanding the order of events in the cell division cycles of Leishmania spp. and Trypanosoma cruzi, adding to previous knowledge of events in Trypanosoma brucei, and highlighting similarities and differences between these trypanosomatids. However, the present understanding of how the cell cycle is regulated by kinases still largely derives from analyses in T. brucei, since convenient genetic tools for analyzing the function of essential regulators – for example, inducible expression systems and/or RNA interference – are still lacking in Leishmania and T. cruzi. While current understanding of the function of some kinases (e.g., some cyclin-dependent kinases, the NDR kinases, aurora, tousled-like and polo-like kinases) is now very good, many more remain to be characterized, as do details of the signal transduction pathways in which they operate. A number of protein kinases have, in recent years, been genetically – and in some cases also chemically – validated as potential novel drug targets for human African trypanosomiasis or leishmaniasis, although only a few, including CRK3:CYC6, CRK3:CYCA, the NDR kinases, PK50 and PK53 and polo-like kinase, have been subjected to high-throughput screening to identify small-molecule inhibitors. However, problems with these screens include a failure to identify potent inhibitors against the parasite enzyme in vitro, a lack of selectivity for the parasite enzyme over the equivalent human enzyme, or poor efficacy against the parasite. Thus, further chemical investigations will be required to generate new compounds with more ideal properties. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5f7c8bfb3880f1ad936b6dd738498913 https://doi.org/10.1002/9783527675401.ch04 |
| رقم الأكسشن: | edsair.doi...........5f7c8bfb3880f1ad936b6dd738498913 |
| قاعدة البيانات: | OpenAIRE |
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