Formulation and Evaluation of Fixed Dose Combination Suppositories Containing Stavudine, Lamivudine and Nevirapine for Pediatric Applications
| العنوان: | Formulation and Evaluation of Fixed Dose Combination Suppositories Containing Stavudine, Lamivudine and Nevirapine for Pediatric Applications |
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| المؤلفون: | N. P. Reddy, B. M. Reddy, K. Sumedha, M. Renuka, Y. Padmavathi |
| المصدر: | Journal of Scientific Research. 7:87-96 |
| بيانات النشر: | Bangladesh Journals Online (JOL), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Nevirapine, Pediatric hiv, business.industry, Stavudine, Fixed-dose combination, Human immunodeficiency virus (HIV), Lamivudine, Pharmacology, Suppository, medicine.disease_cause, medicine, Drug release, business, medicine.drug |
| الوصف: | Suppositories are the convenient way of administering drugs in infants. In view of the lack of suitable pediatric antiretroviral formulations in the market, suppositories containing fixed dose combination (FDC) of stavudine, lamivudine and nevirapine (SLN) were developed to allow administration of the correct weight-related dose in pediatric HIV patients as recommended by WHO. Suppositories containing 10 mg of stavudine, 40 mg of lamivudine and 70 mg of nevirapine were prepared by the fusion method using Witepsol H15 semi-synthetic suppository base. All the prepared suppositories were evaluated for various physical parameters like weight variation, melting point, drug content and hardness. The rate and extent of drug release was evaluated using USP apparatus I and samples were analyzed by a validated UV-multicomponent method. The use of surfactants significantly increased the drug release from formulations manufactured with Witepsol H 15 fatty base. The development of pediatric fixed-dose combination formulations represent a new era and mark an important milestone for children living with HIV/AIDS. |
| تدمد: | 2070-0245 2070-0237 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::603f8ecbca4e8179c323eb5cb612cfbd https://doi.org/10.3329/jsr.v7i3.20858 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........603f8ecbca4e8179c323eb5cb612cfbd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20700245 20700237 |
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