The Study of Apolipoprotein E4 Allele Distribution in Parents of Down’s Syndrome Children as a Risk Factor in Khorasan Razavi Province, Iran
| العنوان: | The Study of Apolipoprotein E4 Allele Distribution in Parents of Down’s Syndrome Children as a Risk Factor in Khorasan Razavi Province, Iran |
|---|---|
| المؤلفون: | Elmira Iranifar, Tayebeh Hamzehloie |
| المصدر: | Open Journal of Genetics. :87-95 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein E, Genetics, Down syndrome, 030219 obstetrics & reproductive medicine, Biology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Nondisjunction, Polymorphism (computer science), medicine, Allele, Risk factor, Genotyping, Allele frequency |
| الوصف: | Backgrounds: Down syndrome (DS) is the most common chromosomal abnormality. The most important factor in DS is increased maternal age so after the age of 35, the risk of Down syndrome in pregnancy increases. Down syndrome can be diagnosed during pregnancy by prenatal screening. Nondisjunction in cell divisions is the main cause of the DS. Apo lipoprotein E is a 317 amino acid glycoprotein that plays an essential role in metabolism and cholesterol transport. Alzheimer’s disease (AD) is one of the symptoms of adults with DS. The apoE allele e4 has been identified as a risk factor for AD and also, played a main role in nondisjunction. An increased risk of AD in mothers of adults with DS has been reported. We hypothesized that young mothers of DS children ( |
| تدمد: | 2162-4461 2162-4453 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::66f9bc1e86dcd3f4da483ba5236cddb5 https://doi.org/10.4236/ojgen.2016.64010 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........66f9bc1e86dcd3f4da483ba5236cddb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21624461 21624453 |
|---|