Highly Enantioselective Synthesis of (R )-3-Alkyl-3-hydroxyindolin-2-ones Including Natural Product (R )-Convolutamydine A Catalyzed by A Primary Amine
التفاصيل البيبلوغرافية
العنوان:
Highly Enantioselective Synthesis of (R )-3-Alkyl-3-hydroxyindolin-2-ones Including Natural Product (R )-Convolutamydine A Catalyzed by A Primary Amine
An efficient strategy for constructing (R)-3-alkyl-3-hydroxyindolin-2-one derivatives catalyzed by a structurally simple and easily prepared primary amine catalyst under mild conditions has been developed. Various isatins and ketones were tolerated, and the desired products were obtained in up to 99 % yield and up to 99 % ee. The biologically active natural product (R)-convolutamydine A was synthesized in 96 % yield and 95 % ee.
