Viability Reduction of Melanoma Cells by Plasma Jet via Inducing G1/S and G2/M Cell Cycle Arrest and Cell Apoptosis
| العنوان: | Viability Reduction of Melanoma Cells by Plasma Jet via Inducing G1/S and G2/M Cell Cycle Arrest and Cell Apoptosis |
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| المؤلفون: | Wen-Long Liao, Guan-Jun Zhang, Xi-Li Wu, Ning Li, Zhengshi Chang, Xing-Min Shi |
| المصدر: | IEEE Transactions on Plasma Science. 42:1640-1647 |
| بيانات النشر: | Institute of Electrical and Electronics Engineers (IEEE), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Nuclear and High Energy Physics, Chemistry, musculoskeletal, neural, and ocular physiology, Melanoma, Long-term potentiation, Cell cycle, Condensed Matter Physics, medicine.disease, In vitro, Cell biology, chemistry.chemical_compound, nervous system, Apoptosis, medicine, Distribution (pharmacology), Viability assay, DNA |
| الوصف: | This paper is aimed to investigate the inhibition effect and mechanism of low-temperature plasma (LTP) on melanoma cells. An argon atmospheric pressure plasma jet is used to generate LTP for the treatment of B16 murine melanoma cells cultured in vitro . LTP treatment time intervals are set as 5, 10, 15, and 20 s, respectively. After being treated with LTP, cell viability, cell apoptosis, cell cycle distribution, and cycle-related proteins expression of melanoma cells are, respectively, measured. It is found that, compared with the control cells, treatment of melanoma cells with 10, 15, and 20 s of plasma, result in a significant reduction in cell viability. Furthermore, investigation demonstrates that LTP may reduce cell viability of melanoma cells via inducing G1/S and G2/M cell cycle arrest and cell apoptosis, and alteration of cell cycle is due to down-modulation of the expression of CyclinB1 and CyclinD1 protein induced by LTP. |
| تدمد: | 1939-9375 0093-3813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::75afc3bd17586aa8e332fc200a7b51e2 https://doi.org/10.1109/tps.2014.2320765 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........75afc3bd17586aa8e332fc200a7b51e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19399375 00933813 |
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