A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage
| العنوان: | A pH-sensitive liposomal co-delivery of fingolimod and ammonia borane for treatment of intracerebral hemorrhage |
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| المؤلفون: | Xiyu Gong, Xingyu Fan, Yongju He, Yingwei Wang, Fangfang Zhou, Binbin Yang |
| المصدر: | Nanophotonics. 11:5133-5142 |
| بيانات النشر: | Walter de Gruyter GmbH, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Electrical and Electronic Engineering, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Biotechnology |
| الوصف: | Intracerebral hemorrhage (ICH) is one of the most devastating types of stroke. This study aims to develop a new drug carrier with hematoma-specific response and high property. pH-sensitive liposomes (PSL) were developed. Fingolimod with ammonia borane were encapsulated in the phospholipid vesicles to integrate two drugs for treating ICH more effectively. pH sensitive PSL-FTY720/AB was characterized for various physicochemical parameters such as shape, surface morphology, vesicle size, zeta-potential, in-vitro drug release in different pH environment, cellular toxicity, in-vivo and ex-vivo tissue accumulation. In vivo results further confirmed that drug-loading nanoparticles effectively protected against ICH-induced brain injury through synergistic effect of anti-inflammation and anti-oxidation. Collectively, the present study confirmed that PSL-FTY720/AB can be an effective, safe, and a novel alternative treatment approach in ICH. |
| تدمد: | 2192-8614 2192-8606 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7e1a60369d6a2da127b1d7b34f068896 https://doi.org/10.1515/nanoph-2022-0496 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........7e1a60369d6a2da127b1d7b34f068896 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21928614 21928606 |
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