Can MR enterography screen for perianal disease in pediatric inflammatory bowel disease?
| العنوان: | Can MR enterography screen for perianal disease in pediatric inflammatory bowel disease? |
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| المؤلفون: | Thomas D. Walters, Rahim Moineddin, Sebastian K. King, Zehour AlSabban, Mary-Louise C. Greer, Jacob C. Langer, Anne M. Griffiths, Nicholas Carman, Peter C Church, Ryan T. Lo |
| المصدر: | Journal of Magnetic Resonance Imaging. 47:1638-1645 |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Crohn's disease, education.field_of_study, business.industry, Population, Steady-state free precession imaging, Gold standard (test), medicine.disease, Inflammatory bowel disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Coronal plane, medicine, 030211 gastroenterology & hepatology, Radiology, Nuclear Medicine and imaging, Stage (cooking), business, Nuclear medicine, education, Kappa |
| الوصف: | Background Pediatric Crohn's disease is associated with perianal disease (PAD). Magnetic resonance enterography (MRE) assesses small bowel involvement in pediatric inflammatory bowel disease (PIBD). Pelvic MRI (P-MRI) is the gold standard for assessing PAD. Purpose To determine if MRE can accurately detect PAD in PIBD, distinguishing perianal fistulae (PAF) from perianal abscesses (PAA), referenced against P-MRI. Study type Retrospective. Population Seventy-seven PIBD patients, 27 females (mean age 14.1 years), with P-MRI and MRE within 6 months. Field strength/sequence 1.5T and 3T; P-MRI: sagittal fat suppressed (FS) T2 fast spin-echo (FSE), coronal short tau inversion recovery, axial T1 FSE, coronal and axial postcontrast FS T1 FSE; MRE: coronal balanced steady-state free-precession (SSFP), coronal cine SSFP, coronal and axial single-shot T2 FS, axial SSFP, coronal ultrafast 3D T1 -weighted gradient echo FS (3D T1 GE), axial diffusion-weighted imaging, coronal and axial postcontrast 3D T1 GE FS. Assessment Two radiologists independently, then by consensus, assessed randomized MRI exams, recording PAF number, location, and length; and PAA number, location, length, and volume. Sensitivity analysis used clinical disease as the gold standard, calculated separately for P-MRI and MRE. Statistical tests Comparing MRE and P-MRI consensus data, sensitivity, specificity, positive, and negative predictive values (P/NPV) were calculated. Inter- and intrareader reliability were assessed using kappa statistics. Results P-MRI and MRE were paired, detecting PAD in 73 patients, PAF in 63, and PAA in 31 P-MRI. MRE sensitivities, specificities, PPV, and NPV were: PAD 82%, 100%, 100%, 23%; PAF 74%, 71%, 92%, 38%; PAA 51%, 85%, 69%, 72%; clinical 82%, 22%, 37%, 69%; clinical P-MRI 96%, 8%, 37%, 80%. MRE interreader agreement for PAD was moderate (kappa = 0.51 [0.29-0.73]), fair for PAF and PAA. Data conclusion Using a standard technique, MRE can detect PAD with high specificity and moderate sensitivity in PIBD, missing some PAF and small PAA. Level of evidence 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1638-1645. |
| تدمد: | 1053-1807 1638-1645 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7ee6f0d08d991e78766738f014197e21 https://doi.org/10.1002/jmri.25888 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........7ee6f0d08d991e78766738f014197e21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10531807 16381645 |
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