Clinical significance of liver biopsy in chronic hepatitis B patients with persistently normal transaminase
| العنوان: | Clinical significance of liver biopsy in chronic hepatitis B patients with persistently normal transaminase |
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| المؤلفون: | Tu Fang Chen, Yan Long Zhao, Zhuo Ying Qin, Jian Sheng Zuo, Ke Cheng Xu, Zhi Rong Wu, Bei Hai Wei, Liu Ming Yang |
| المصدر: | Chinese Journal of Digestive Diseases. 3:150-153 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, Necrosis, medicine.diagnostic_test, business.industry, Gastroenterology, medicine.disease, Group B, Transaminase, HBeAg, Fibrosis, Internal medicine, Liver biopsy, Medicine, Elevated transaminases, Clinical significance, medicine.symptom, business |
| الوصف: | OBJECTIVE: The aim of this study was to study the clinical significance of liver biopsy for individuals who had chronic hepatitis B virus infection and persistently normal serum transaminases for more than 6 months. METHODS: A total of 452 patients with positive hepatitis B surface antigen for over 6 months underwent percutaneous liver biopsy. All liver biopsy specimens were assessed by experienced liver pathologists blinded to the liver biochemistry, and were scored according to the modified criteria of grade and stage of chronic hepatitis. Patients were divided into four groups: group A and group C patients had normal transaminases, and were hepatitis B e antigen (HBeAg) positive and HBeAg negative, respectively; group B and group D patients had elevated transaminases, and were HBeAg positive and HBeAg negative, respectively. RESULTS: All patients had necrosis and inflammation in the liver. Patients with increased serum transaminases had a significantly higher grade (G) of hepatic necrosis and inflammation and more severe (S) fibrosis compared with patients with normal transaminases (P |
| تدمد: | 1443-9573 1443-9611 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::820d482afa0697618b2610760a44e144 https://doi.org/10.1046/j.1443-9573.2002.00093.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........820d482afa0697618b2610760a44e144 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14439573 14439611 |
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