Polymorphisms and haplotypes of IL2RA , IL10 , IFN G , IRF5, and CCR2 are associated with Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in children
| العنوان: | Polymorphisms and haplotypes of IL2RA , IL10 , IFN G , IRF5, and CCR2 are associated with Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in children |
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| المؤلفون: | Guohua Chen, Hongman Xue, Xiao-Jun Wu, Junbin Huang, Nannan Tang, Hong-Gui Xu, Chun Chen |
| المصدر: | Pediatric Blood & Cancer. 68 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Hemophagocytic lymphohistiocytosis, business.industry, Haplotype, hemic and immune systems, Single-nucleotide polymorphism, Hematology, medicine.disease, 03 medical and health sciences, Interleukin 10, 0302 clinical medicine, Oncology, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, parasitic diseases, Pediatrics, Perinatology and Child Health, Genotype, Immunology, medicine, Interferon gamma, Allele, business, IRF5, 030215 immunology, medicine.drug |
| الوصف: | Objective Cytokine storms are central to the development of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH). Previous studies have shown that single-nucleotide polymorphisms (SNPs) of cytokine genes may be associated with the development of EBV-HLH in children. As such, we investigated the association between susceptibility to EBV-HLH in children and SNPs and haplotypes of genes encoding interleukin-2 receptor subunit alpha (IL2RA), interleukin-10 (IL10), interferon gamma (IFNG), interferon regulatory factor 5 (IRF5), and C-C chemokine receptor 2 (CCR2). Methods Sixty-six children with EBV-HLH and 58 healthy EBV-seropositive controls were enrolled in this study. SNPs of IL2RA rs2104286, rs12722489, and rs11594656; IL10 rs1800896, rs1800871, and rs1800872; IFNG rs2430561, IRF5 rs2004640, and CCR2 rs1799864 were assayed and genotyped using the SNaPshot technique. Results Frequencies of the A allele of IL2RA rs2104286 and IL10 rs1800896, and C allele of IL-10 rs1800872 were significantly higher in the EBV-HLH group than in the control group. The AA genotype of IL2RA rs2104286 and IL10 rs1800896, and the CC genotype of IL10 rs1800872 might be associated with a significantly high risk of EBV-HLH. However, the frequencies of genotypes and alleles of IL2RA rs2104286, IL10 rs1800871, IFNG rs2430561, IRF5 rs2004640, and CCR2 rs1799864 were similar in both groups. Additionally, IL2RA AGT (rs2104286-rs12722489-rs11594656) and IL10 ACC (rs1800896-rs1800871-rs1800872) haplotypes were also associated with an increased risk of EBV-HLH. Conclusions SNPs of IL2RA rs2104286, IL10 rs1800896 and rs1800872 and the haplotypes of IL2RA AGT and IL10 ACC were highly associated with susceptibility to EBV-HLH in children. |
| تدمد: | 1545-5017 1545-5009 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::873ec6cb38ce25d1082f4975d689e58f https://doi.org/10.1002/pbc.29097 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........873ec6cb38ce25d1082f4975d689e58f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15455017 15455009 |
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