Elastography in the Diagnosis of Non-Alcoholic Fatty Liver Disease
| العنوان: | Elastography in the Diagnosis of Non-Alcoholic Fatty Liver Disease |
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| المؤلفون: | Alla Sedova, Chavdar S Pavlov, Vladimir Ivashkin, Anna D. Karaseva, Elena Shirokova, Aliya M. Alieva |
| المصدر: | Annals of the Russian academy of medical sciences. 74:5-13 |
| بيانات النشر: | Paediatrician Publishers LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, business.industry, Ultrasound, Fatty liver, General Medicine, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, 030220 oncology & carcinogenesis, Liver biopsy, Nonalcoholic fatty liver disease, medicine, 030211 gastroenterology & hepatology, Radiology, Elastography, Steatosis, business, Transient elastography |
| الوصف: | Currently, there has been a progressive increase in prevalence of one of the most common diffuse chronic liver diseases ― non-alcoholic fatty liver disease (NAFLD). Assessment of the stages of liver fibrosis and steatosis is prognostically significant in diagnosis of NAFLD. Routine diagnostic methods are either not able to accurately assess the severity of fibrosis and steatosis (ultrasound, laboratory tests), or cannot be used as a simple screening tool (liver biopsy) due to such limitations as invasiveness, dependence on pathologist qualification, high cost, and limited region of interest. Over the last two decades, the great progress has been made in non-invasive visualization of pathological changes in liver diseases. In this review, we examined the diagnostic characteristics of the most widely used non-invasive imaging methods in clinical practice, available for quantitative determination of fat and fibrosis in the liver: transient elastography with controlled attenuation parameter (CAP), acoustic radiation force impulse (ARFI) and shear wave elastography (SWE). Comparing these methods and their limitations, we came to conclusion, that elastographic methods (slightly more ARFI and SWE) are able to verify the F3, F4 stages of fibrosis in NAFLD with high sensitivity and specificity (90%); however, they are less accurate for early stages. Elastographic techniques have moderate accuracy in identifying the degree of steatosis due to the lack of uniform standardized cut-off values of CAP. |
| تدمد: | 2414-3545 0869-6047 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::890e6a56efbe92b3cef9791772ceab74 https://doi.org/10.15690/vramn1071 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........890e6a56efbe92b3cef9791772ceab74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24143545 08696047 |
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