Vitamin A deficient mice have a decreased ability to clear the enteric pathogen, Citrobacter rodentium and increased mortality during infection (MUC4P.851)
| العنوان: | Vitamin A deficient mice have a decreased ability to clear the enteric pathogen, Citrobacter rodentium and increased mortality during infection (MUC4P.851) |
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| المؤلفون: | Kaitlin McDaniel, Katherine Restori, Mary Kennett, A. Ross, Margherita Cantorna |
| المصدر: | The Journal of Immunology. 192:133.27-133.27 |
| بيانات النشر: | The American Association of Immunologists, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Vitamin A is essential for normal immune function and vitamin A supplementation has been shown to decrease childhood mortality from infectious respiratory and diarrheal diseases. In this study, we determined that vitamin A sufficient (A+) mice were able to clear a Citrobacter rodentium infection while vitamin A deficient (A-) mice shed over 10,000 C. rodentium/g feces up to 37 d following infection. A- mice also had increased crypt hyperplasia compared to A- mice indicating that C. rodentium is a chronic infection in A- mice. Supplementation of A- mice with retinoic acid (RA) at d 0 or 14 post-infection resulted in the clearance of C. rodentium. A- mice had decreased frequencies of colonic CD8αα+ Tcrβ+ T cells and an increased frequency of CD4+ Tcrβ+ T cells. A- mice had reduced survival rates (58%) following C. rodentium infection while 100% of A+ mice survived. RA supplementation beginning on the day of infection resulted in 100% survival of the A- mice. The increased lethality of the C. rodentium infection in A- mice corresponded with the systemic spread of C. rodentium. T cells are critical for the prevention of the systemic spread and increased lethality of C. rodentium infection since mice without T cells are unable to clear an infection. The data suggest that vitamin A regulation of mucosal and systemic T cells is critical for survival and clearance of a C. rodentium infection. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::893e253b5a1c243284f37d2c891b0e55 https://doi.org/10.4049/jimmunol.192.supp.133.27 |
| رقم الأكسشن: | edsair.doi...........893e253b5a1c243284f37d2c891b0e55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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