A bifunctional MXene-modified scaffold for photothermal therapy and maxillofacial tissue regeneration
| العنوان: | A bifunctional MXene-modified scaffold for photothermal therapy and maxillofacial tissue regeneration |
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| المؤلفون: | Rui Luo, Yanling Yan, Han Liu, Hao Liu, Fengji Li, Yaru Fan, Huiru Zou, Ruixin Li, Yanan Wang |
| المصدر: | Regenerative Biomaterials. |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Biomaterials, Scaffold, chemistry.chemical_compound, Durapatite, Biocompatibility, Chemistry, Tumor growth, Tumor cells, Photothermal therapy, Bifunctional, Biomedical engineering |
| الوصف: | Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumours in the oral and maxillofacial regions and is highly malignant and prone to recur despite the development of various effective treatments, including surgery and chemoradiotherapy. Actually, it is difficult to ensure the complete elimination of tumour cells, and maxillofacial bone defects caused by surgery are hard to heal by themselves. In addition, chemoradiotherapy can bring serious side effects. Therefore, it is imperative to develop a postoperative therapy to kill residual squamous cancer cells and repair bone defects without any side effects. Here, we prepared a three-dimensional (3D) scaffold by a 3D printing technique and freeze-drying method, which contained collagen, silk and hydroxyapatite (CSH) and was functionalized with MXene nanosheets (M-CSH). The considerable photothermal effect with long-term stability can significantly kill squamous CAL-27 cancer cells in vitro and inhibit tumour growth in vivo, increasing the probability of the M-CSH scaffold being applied in the photothermal therapy of OSCC. Moreover, the cell proliferation- and osteogenic-related protein expression of mouse embryonic osteogenic precursors (MC3T3-E1) indicated excellent biocompatibility and osteogenic activity of M-CSH scaffolds. The good compression modulus (52.83 ± 2.25 kPa) and in vivo bone formation performance made it possible to be used as reconstructive materials for bone defects. This scaffold is likely promising in future tissue engineering, especially for the multifunctional treatment of maxillofacial tumours. |
| تدمد: | 2056-3426 2056-3418 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8e649c8f4ca7281760431bec1228d330 https://doi.org/10.1093/rb/rbab057 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........8e649c8f4ca7281760431bec1228d330 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20563426 20563418 |
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