Myelodysplastic syndrome following chimeric antigen receptor T-cell therapy treated with allogenic stem cell transplantation
| العنوان: | Myelodysplastic syndrome following chimeric antigen receptor T-cell therapy treated with allogenic stem cell transplantation |
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| المؤلفون: | Khalil Saleh, Ahmadreza Arbab, David Ghez, Camille Bigenwald, Sophie Cotteret, Christophe Marzac, Florence Pasquier, Sylvain Pilorge, Véronique Saada, Véronique Vergé, Vincent Ribrag, Cristina Castilla-Llorente |
| المصدر: | Immunotherapy. 15:401-407 |
| بيانات النشر: | Future Medicine Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Oncology, Immunology, Immunology and Allergy |
| الوصف: | Chimeric antigen receptor (CAR) T-cell therapy is currently approved for the treatment of B-cell non-Hodgkin lymphomas and B-cell acute lymphoblastic leukemia. Prolonged hematological toxicity is an emergent concern following CAR T cells and occurred in 30% of patients with unknown mechanism. Few cases of myelodysplastic syndrome (MDS) following CAR T-cell therapy were reported and attributed to previous chemotherapies in heavily pretreated patients. The authors report the case of a patient with diffuse large B-cell lymphoma treated with axicabtagene ciloleucel who developed prolonged hematological toxicity by day 28. During the follow-up, the diagnosis of MDS was made. The patient underwent allogenic hematological stem cell transplantation. The patient remains in complete remission of his lymphoma and MDS 19 months after hematological stem cell transplantation. |
| تدمد: | 1750-7448 1750-743X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::95c3631769382247ca1a18ae3233622e https://doi.org/10.2217/imt-2022-0205 |
| رقم الأكسشن: | edsair.doi...........95c3631769382247ca1a18ae3233622e |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17507448 1750743X |
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