Development and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles
| العنوان: | Development and Demonstration of a Safer Protocol for the Synthesis of 5-Aryltetrazoles from Aryl Nitriles |
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| المؤلفون: | Simon Leung, Mark Lindrud, Daniel S. Treitler |
| المصدر: | Organic Process Research & Development. 21:460-467 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Nitrile, 010405 organic chemistry, Hydrochloride, Aryl, Organic Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Sodium azide, Phenol, Organic chemistry, Amine gas treating, Tetrazole, Reactivity (chemistry), Physical and Theoretical Chemistry |
| الوصف: | The search for a faster, safer protocol for the direct synthesis of 5-aryltetrazoles from aryl nitriles in the presence of sodium azide and an amine hydrochloride salt led to the discovery of a buffered system comprised of BnNH2, BnNH2·HCl, and NaN3. After optimization of reaction conditions and a thorough investigation of reaction safety, the procedure was demonstrated for the synthesis of several hundred grams of 4-chloro-2-(2H-tetrazol-5-yl)phenol. The generality of the developed reaction conditions was established by a small-scale reactivity screen using 16 additional aryl and heteroaryl nitrile substrates. |
| تدمد: | 1520-586X 1083-6160 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::99b737e5df4711bca19f4a0bbc700791 https://doi.org/10.1021/acs.oprd.7b00016 |
| رقم الأكسشن: | edsair.doi...........99b737e5df4711bca19f4a0bbc700791 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1520586X 10836160 |
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