Enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using new chiral P,N ligands composed of (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines
| العنوان: | Enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using new chiral P,N ligands composed of (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines |
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| المؤلفون: | Toshiaki Morimoto, Masato Suzuki, Yoichi Yamaguchi, Akihito Saitoh |
| المصدر: | Tetrahedron Letters. 41:10025-10029 |
| بيانات النشر: | Elsevier BV, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Chalcone, Chemistry, Ligand, Organic Chemistry, Enantioselective synthesis, Diethylzinc, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, Cyclohexenone, Drug Discovery, Copper catalyzed, Alkyl, Conjugate |
| الوصف: | New P,N ligands prepared from (S)-2-alkyl-2-aminoethylphosphines and α-substituted pyridines are efficient chiral ligands for the copper-catalyzed conjugate addition of diethylzinc to 2-cyclohexen-1-one and chalcone. The best result (90–91% ee) for the cyclohexenone was obtained with Cu(OTf)2 (0.7–1 mol%) and a P,N ligand 4 derived from (S)-1-(diphenylphosphino)-3-methyl-2-butanamine and 6-methylpyridine-2-carboxaldehyde. |
| تدمد: | 0040-4039 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a10eeabbf049b9eb5a86d10a791b18ec https://doi.org/10.1016/s0040-4039(00)01789-5 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a10eeabbf049b9eb5a86d10a791b18ec |
| قاعدة البيانات: | OpenAIRE |
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