| الوصف: |
Background miRNA acts as a disease regulator. An evolutionary approach to disease could discover factors such as diagnosis, treatment, and prognosis prediction. Therefore, the expression level and expression pattern of each cancer type of transposable elements (TEs)-related disease-related miRNAs were identified, and their evolutionary patterns were identified. Methods The 34 miRNAs were compared by stage survival, and tumor status in 33 carcinomas of TCGA. The expression levels were compared by t-test, and presented as differentially expressed miRNAs (DEMs). For DEMs showing statistically specific expression patterns for a total of three conditions (normal and cancer, early and advanced stage, and survival), interactions with related genes in a total of 10 species including humans were compared. The enrichment term was discovered for the gene-miRNA interaction. Results In 18 of the 33 carcinomas, at least one miRNA was retrieved by p < 0.05 and |fold change| > 0.05 conditions. A total of 128 DEMs for 9 miRNAs were presented. Based on the TargetScan database, interactions between miRNAs and genes in a total of 10 species including the human were confirmed. The evolutionarily best conserved miR-130a was observed in all 10 species, whereas miR-151a was observed only in the human. GO terms of related genes were selected for miRNAs commonly found in each species. Conclusions Evolutionary analysis of TE-derived disease-associated miRNAs was performed, and the evolutionarily conserved miR-130a-related carcinomas were renal and thyroid cancers. Human and rhesus monkey-specific miR-625 was associated with a variety of carcinomas. |
