Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report
| العنوان: | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
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| المؤلفون: | Kwang Ho Yang, Yoonhong Kim, Je Ho Ryu, Dong Il Kim, Jae Ryong Shim, Byung Hyun Choi, Hyun Jung Lee, Tae Beom Lee |
| المصدر: | Korean Journal of Transplantation. 33:146-152 |
| بيانات النشر: | The Korean Society for Transplantation, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Transplantation, medicine.medical_specialty, Proteinuria, business.industry, medicine.medical_treatment, Immunology, Urology, Mild proteinuria, Pancreas transplantation, medicine.disease, Diabetic nephropathy, Calcineurin, Diabetes mellitus, medicine, medicine.symptom, business, Retinopathy |
| الوصف: | Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinuria after successful pancreas transplantation alone without evidence of calcineurin inhibitor (CNI) toxicity. A 22-year-old female patient with type I diabetes mellitus underwent pancreas transplantation alone. The patient already had retinopathy and mild proteinuria, which in this case, may mean diabetic nephropathy. Her glucose levels were managed within the normal range after successful pancreas transplantation. However, the amount of proteinuria fluctuated. Kidney needle biopsy was performed owing to severe elevation of proteinuria, 2 years after the transplantation. Electron microscopy revealed diabetic glomerulosclerosis without evidence of CNI toxicity. This case indicates that diabetic nephropathy can be aggravated after pancreas transplantation, despite well-managed glucose levels and absence of CNI toxicity. |
| تدمد: | 2671-8804 2671-8790 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a90f0a2c56b3afaa47602975b2eaca41 https://doi.org/10.4285/jkstn.2019.33.4.146 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........a90f0a2c56b3afaa47602975b2eaca41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26718804 26718790 |
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