Stepwise ring closure in penicillin biosynthesis. Intitial β-lactam formation
| العنوان: | Stepwise ring closure in penicillin biosynthesis. Intitial β-lactam formation |
|---|---|
| المؤلفون: | Leslie D. Field, Jack E. Baldwin, Robert M. Adlington, Simon E. Moroney, Hong-Hoi Ting |
| المصدر: | J. Chem. Soc., Chem. Commun.. :984-986 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Chemistry, Stereochemistry, Substrate (chemistry), Ring (chemistry), Penicillin, chemistry.chemical_compound, Biosynthesis, Biochemistry, Cephalosporium acremonium, Lactam, medicine, Molecular Medicine, Incubation, Penicillin biosynthesis, medicine.drug |
| الوصف: | Incubation of a 1 : 1 mixture of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (L,L,D-ACV) and L,L,D-A[3,3-2H2]CV with a cell-free extract of isopenicillin N synthetase from Cephalosporium acremonium results in preferential conversion of the fully protiated substrate into isopenicillin N; alternatively a similar experiment with a 1 : 1 mixture of L,L,D-ACV and L,L,D-AC[3-2H]V gave isopenicillin N without isotopic discrimination between the two substrates. |
| تدمد: | 0022-4936 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c1f309eca00f65f8daaf3fae96a5466e https://doi.org/10.1039/c39840000984 |
| رقم الأكسشن: | edsair.doi...........c1f309eca00f65f8daaf3fae96a5466e |
| قاعدة البيانات: | OpenAIRE |
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