A five-site comprehensive mathematical model was developed to simulate the steady-state behavior of industrial slurry polymerization of ethylene in multistage continuous stirred tank reactors. More specifically, the effects of various operating conditions ( i.e ., inflow rates of catalyst, hydrogen and comonomer) on the molecular structure and properties of polyethylene ( i.e ., M w , M n , polydispersity index ( I PD ), melt index, density, etc .) are fully assessed. It is shown that the proposed comprehensive model is capable of simulating the steady-state operation of an industrial slurry stirred tank reactor series. It is demonstrated that changing the catalyst flow rate, changes simultaneously the mean residence-time in both reactors, which plays a significant role on the establishment of polyethylene architecture properties such as molecular mass and I PD . The melt index and density of polyethylene are mainly controlled by hydrogen and comonomer concentration, respectively.