Establishment of a Zebrafish Xenograft Model for in Vivo Investigation of Nasopharyngeal Carcinoma
| العنوان: | Establishment of a Zebrafish Xenograft Model for in Vivo Investigation of Nasopharyngeal Carcinoma |
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| المؤلفون: | Enyu Huang, Haofeng Huang, Longji Wu, Binbin Li, Zhiwei He, Jingjing Zhang |
| المصدر: | Cell Transplantation. 31:096368972211160 |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Transplantation, Biomedical Engineering, Cell Biology |
| الوصف: | Nasopharyngeal carcinoma (NPC) is a unique malignant tumor of the head and neck. Despite higher survival rates by the combination of radiotherapy and chemotherapy, the recurrence or metastasis of NPC still occurs at about 10%. Therefore, there is urgent demand to develop more effective in vivo models for preclinical trials to investigate the mechanisms of NPC development and progression and to explore better treatment approaches. In this study, we transplanted human NPC CNE1 cells into zebrafish embryos to establish a xenograft model of NPC, where the proliferation and invasion behaviors of NPC cells were investigated in vivo. Combining in vitro and in vivo analyses, we found that activating transcription factor 7 (ATF7) was involved in the occurrence and development of NPC regulated by peptidyl-prolyl cis- trans isomerase NIMA-interacting 1 (Pin1). The zebrafish NPC xenograft model established here thereby provides an in vivo tool for exploring the occurrence and development of NPC, which may help to identify new tumor markers and develop new therapeutic strategies for the treatment of NPC. |
| تدمد: | 1555-3892 0963-6897 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c6bb88931c29b674ae1e81fcb64e9ef9 https://doi.org/10.1177/09636897221116085 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........c6bb88931c29b674ae1e81fcb64e9ef9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15553892 09636897 |
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