Natural killer cells suppress B cell immunity through perforin-dependent mechanisms (IRC4P.617)
| العنوان: | Natural killer cells suppress B cell immunity through perforin-dependent mechanisms (IRC4P.617) |
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| المؤلفون: | Carolyn Rydyznski, Erik Karmele, Sarah Mahl, Stephen Waggoner |
| المصدر: | The Journal of Immunology. 194:57.34-57.34 |
| بيانات النشر: | The American Association of Immunologists, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Accumulating evidence suggests that natural killer (NK) cells are critical regulators of antiviral T cells during chronic infection. We find that NK cells are also potent inhibitors of germinal center (GC) responses and the generation of long-lived B cell immunity after acute infection. A similar suppressive function was noted for NK cells after immunization with the non-replicating T cell-dependent antigen NP-KLH, suggesting that strategies to subvert NK cell-mediated inhibition may be able to improve vaccine responses. To determine whether cytotoxic function is important for this regulatory activity, we examined the contributions of perforin-containing granules and the death receptor Fas. NK cell inhibition of GCs was intact in Fas-deficient lpr mice but absent in perforin-deficient mice, thereby implicating granule-mediated cytotoxicity in this process. Moreover, we found that NK cells acted in a perforin-dependent manner during the first three days post-immunization to suppress generation of follicular helper CD4 T cell (Tfh) responses. The suppression of Tfh by NK cells was independent of the presence or absence of B cells, while CD4 T cells were required for development of virus-specific B cells. Thus, NK cells determine the quality and magnitude of B cell responses following immunization predominately via perforin-dependent repression of Tfh responses. This immunoregulatory process represents an innovative target for interventions aimed at enhancing vaccine efficacy. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::c90e4b05e7a111a8844e670c2c2bbd24 https://doi.org/10.4049/jimmunol.194.supp.57.34 |
| رقم الأكسشن: | edsair.doi...........c90e4b05e7a111a8844e670c2c2bbd24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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