Severity of infectious mononucleosis (IM) correlates with the frequency of crossreactive influenza A virus (IAV)-M1 and Epstein Barr virus (EBV)-BMLF-1-specific CD8 T cells (HUM8P.345)
| العنوان: | Severity of infectious mononucleosis (IM) correlates with the frequency of crossreactive influenza A virus (IAV)-M1 and Epstein Barr virus (EBV)-BMLF-1-specific CD8 T cells (HUM8P.345) |
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| المؤلفون: | Liisa K. Selin, Nuray Aslan, Levi Watkin, Anna Gil, Katherine Luzuriaga |
| المصدر: | The Journal of Immunology. 192:185.20-185.20 |
| بيانات النشر: | The American Association of Immunologists, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | During EBV-associated IM IAV-specific crossreactive memory T cells are activated and play a role in disease severity. In HLA-A2+ IM patients, influenza M1-58 (IAV-M1)-specific CD8 memory T cell responses crossreacted with two different EBV lytic epitopes, BMLF1-280 (17/29) and BRLF1-109 (19/20). Furthermore, 11/22 IM patients demonstrated some intra-viral crossreactivity between EBV-BRLF1 and -BMLF1 responses. Disease severity of IM directly correlated with significantly increased frequencies of crossreactive IAV-M1/EBV-BMLF1, IAV-M1, and EBV-BMLF1 specific CD8 cells, and with mean viral load over the first 5 weeks of infection. Disease severity did not correlate with BRLF1 or M1/BRLF1 crossreactive responses. When severity of IM was scored and patients were assigned to either mild or severe groups, disease severity correlated with specific TCR Vb usage in IAV-M1 population suggesting that TcR selection is driving disease outcome. Consistent with IAV-M1 and EBV-BMLF1 responses driving increased immunopathology was the observation that patients with severe disease had significantly more IAV-M1 and EBV-BMLF1 cells producing IFNg/MIP1-b in response to antigen as compared to patients with mild disease. These results suggest that T cell crossreactivity impacts T cell selection and function and ultimately disease outcome. Insights on these issues are important for the intelligent design of vaccines and to develop therapeutic interventions for virally induced disease. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::db7fb73db2a273b531a453cc05befae2 https://doi.org/10.4049/jimmunol.192.supp.185.20 |
| رقم الأكسشن: | edsair.doi...........db7fb73db2a273b531a453cc05befae2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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