The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy
| العنوان: | The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy |
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| المؤلفون: | Peter H. Katelaris, Francis Seow, D. B. Jones, B. P. C. Lin, Gordon Jung-Hyuk Park, D. G. Le Couteur, Meng C. Ngu |
| المصدر: | Alimentary Pharmacology and Therapeutics. 22:395-403 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Breath test, medicine.medical_specialty, Hepatology, Receiver operating characteristic, Reverse-transcriptase inhibitor, medicine.diagnostic_test, business.industry, Gastroenterology, Lamivudine, medicine.disease, chemistry.chemical_compound, chemistry, Fibrosis, Internal medicine, Immunology, medicine, Pharmacology (medical), Viral disease, Liver function, business, Caffeine, medicine.drug |
| الوصف: | Summary Background : The 13C-caffeine breath test is a non-invasive, quantitative test of liver function. Aim : To determine the utility of the 13C-caffeine breath test in chronic hepatitis B virus and its ability to monitor response to lamivudine. Methods : Forty-eight chronic hepatitis B virus patients and 24 controls underwent the 13C-caffeine breath test. In 28 patients commenced on lamivudine, 13C-caffeine breath tests were performed at 1 week (n = 12) and after 1 year of therapy. Results : Patients with Metavir F0–1 fibrosis (2.30 ± 1.02 Δ‰ per 100 mg caffeine) had a 13C-caffeine breath test similar to controls (2.31 ± 0.85, P = 0.96). However, patients with F2–3 fibrosis (1.59 ± 0.78, P = 0.047) and cirrhotic patients (0.99 ± 0.33, P = 0.001) had a decreased 13C-caffeine breath test. Fibrosis correlated best with the 13C-caffeine breath test (rs = −0.62, P |
| تدمد: | 1365-2036 0269-2813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e1bb94eb30be6ea4f76007ae3bd01c26 https://doi.org/10.1111/j.1365-2036.2005.02623.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........e1bb94eb30be6ea4f76007ae3bd01c26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652036 02692813 |
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