We describe 16 patients with HIV-associated nephropathy. 8/16 had heavy proteinuria and a morphologic pattern of focal segmental glomerulosclerosis on renal biopsy. Only half of them had Sida. Despite Retrovir and ACE inhibitors 5/8 died, 2 of them as a consequence of progressive renal failure. One patient, only lightly immunodepressed, had IgA nephropathy without renal insufficiency. 8/16 had tubulo-interstitial nephropathy or glomerulonephritis associated with opportunistic infections or drugs.