A systematic review of skin ageing genes reveals a pleiotropic landscape where skin colour genes and chromosomal band 16q24.3 genes may drive skin ageing
التفاصيل البيبلوغرافية
العنوان:
A systematic review of skin ageing genes reveals a pleiotropic landscape where skin colour genes and chromosomal band 16q24.3 genes may drive skin ageing
Skin ageing is the result of intrinsic genetic and extrinsic lifestyle factors. However, there is no consensus on skin ageing phenotypes and ways to quantify them. In this systematic review, we first carefully identified 56 skin ageing phenotypes from multiple literature sources and sought the best photo-numeric grading scales to evaluate them. Next, we conducted a systematic review on all 44 Genome-wide Association Studies (GWAS) on skin ageing published to date and identified genetic risk factors (2,349 SNPs and 366 genes) associated with skin ageing. We identified 19 promising SNPs found to be significantly (p-Value
